HMG-CoA Reductase Activity Assay Kit (Colorimetric)

This product is manufactured by BioVision, an Abcam company and was previously called K588 H mg-CoA Reductase Activity/Inhibitor Screening Kit (Colorimetric). K588-100 is the same size as the 100 test size of ab204701.

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. The enzyme is target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol.